Histamine is often thought of in relation to hay fever and skin reactions, such as atopic eczema, but did you know that histamine is also implicated in digestive health conditions including reflux, irritable bowel syndrome (IBS) and Inflammatory Bowel Disease (IBD)?
Today’s article, the second in the series, focuses on histamine and its link to gut health and includes:
What role does histamine play in digestion?
Histamine, a neurotransmitter, and immune system mediator, plays a crucial role in a whole range of processes and is found throughout the body, including the gastrointestinal tract.
Histamine is released by mast cells and basophils in response to allergens, pathogens, tissue damage, amongst other stimuli and plays a dual role in the digestive system, at times being pro-inflammatory and at others anti-inflammatory. It has several roles including (1):
Which digestive disorders are linked to histamine?
What are the possible triggers of a histamine reaction in the gut?
In summary, here are my top tips for managing histamine as a trigger for gut disorders:
If on medication, please speak to your GP/consultant before making any changes to your diet.
If you are interested in histamine and its impact on symptoms, this article is the second in a series I am currently publishing. The series will include:
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I’m Jessica Fonteneau, the Eczema and Digestive Health Nutrition Expert. I’ve worked with hundreds of clients to help them change their diets, better manage their flares, and find relief.
My vocation is to help those with eczema and digestive issues, because I have suffered with these interlinked conditions since I was 6 months old, and I truly know what it is like to experience these debilitating conditions.
Every client I have ever worked with has their own triggers and ideal nutrition. There is no such thing as ‘one-size-fits-all’. Whether you work with me one-to-one or use my guided tools, my objective is to help you uncover what works best for you, so that you take back control and experience relief.
My guided programmes are only suitable for adults as children have very specific nutrition requirements. I do, however, work with many child clients as part of my clinic.
I also offer two free communities for adults and adults caring for children with eczema and digestive symptoms, feel free to come and join us and get some well-deserved support.
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Interested in what I do and who I am? Go to my website: www.jessicafonteneaunutrition.com
1. Chen M, Ruan G, Chen L, Ying S, Li G, Xu F, et al. Neurotransmitter and Intestinal Interactions: Focus on the Microbiota-Gut-Brain Axis in Irritable Bowel Syndrome. Front Endocrinol (Lausanne). 2022;13(February):1–12.
2. Rettura F, Bronzini F, Campigotto M, Lambiase C, Pancetti A, Berti G, et al. Refractory Gastroesophageal Reflux Disease: A Management Update. Front Med. 2021;8(November):1–19.
3. Zaterka S, Marion SB, Roveda F, Perrotti MA, Chinzon D. Historical perspective of gastroesophageal reflux disease clinical treatment. Arq Gastroenterol. 2019;56(2):202–8.
4. Melgarejo E, Medina MÁ, Sánchez-Jiménez F, Urdiales JL. Targeting of histamine producing cells by EGCG: a green dart against inflammation? J Physiol Biochem [Internet]. 2010;66(3):265–70. Available from: https://doi.org/10.1007/s13105-010-0033-7
5. Kanikowska A, Janisz S, Mańkowska-Wierzbicka D, Gabryel M, Dobrowolska A, Eder P. Management of Adult Patients with Gastrointestinal Symptoms from Food Hypersensitivity—Narrative Review. Vol. 11, Journal of Clinical Medicine. 2022.
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